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The approval of semaglutide is based on part 1 of the ESSENCE phase 3 clinical trial, with full approval contingent on the confirmation of efficacy and safety outcomes from part 2 of the same study

10.1172/jci.insight.140532 107 WoottenD.ReynoldsC

Take these steps in order: Tell your prescribing doctor what changed and when Reach out to a hearing care provider for an evaluation Never stop a prescribed medication on your own Ask whether a dose change or a different drug is possible Early action gives you the best chance to keep the hearing you have

Most patients experience gastrointestinal effects (nausea, constipation, occasional vomiting) during dose escalation