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Because the equilibrium of this reversible reaction favours SAH formation, which is a potent methylation inhibitor, Hcy and adenosine need to be metabolized to maintain low SAH levels

If the trajectory of every other GLP-1 medication tells us anything, it is that the gap between clinical promise and patient access can be vast, painful, and deliberately engineered

The observation was characteristically self-deprecating, but it missed something essential

| Concentration | BAC Water | Doses at 1.0mg | Doses at 2.4mg | |---------------|-----------|----------------|----------------| | 5mg/mL | 2.0mL | 10 doses | ~4 doses | | 2.5mg/mL | 4.0mL | 10 doses | ~4 doses | **Best practice:** 2.0mL BAC water gives a clean 5mg/mL concentration