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Addressing these challenges necessitates meticulous nanoparticles design, ensuring biocompatibility, target specificity, and safe degradation post-treatment within the body [105]

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Cultured human umbilical vein ECs (HUVECs), in particular, express typical molecular markers, including CD31, von Willebrand factor (VWF), CD34, intercellular adhesion molecule-1 (ICAM-1), E-selectin, vascular cell adhesion molecule-1 (VCAM-1), and angiotensin I converting enzyme (ACE) [15, 16] (Table 1)