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To estimate AORs and 95% CIs for gout by status, duration, intensity, and cumulative smoking dose in study population B, multiple logistic regression analyses were performed in the same manner as in the hyperuricemia analyses described above

If treatment was discontinued due to adverse effects, particularly serious ones such as pancreatitis, severe gastrointestinal symptoms, or significant adverse reactions, potential donors should wait until they have fully recovered and been medically cleared

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It binds into the ERR ligand pocket and stabilizes the receptor's active conformation , increasing its affinity for co-activators (PGC-1alpha and alternative co-activators) even in the absence of exercise-induced PGC-1alpha induction