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The 1980s and 1990s saw the identification of multiple isoforms, revealing their specialized roles in different cellular compartments

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More recently, others have found elevated expression of the NAD + glycohydrolase enzyme CD38 in the ovary during reproductive ageing, and showed that blocking the degradation of NAD + through small molecule inhibition of CD38 can prolong female reproductive lifespan (Perrone et al, 2023

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18 British Crop Production Council [BCPC] (2022)

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