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The skin barrier in nummular eczema shows specific defects different from other eczemas

Accumulated p53 is stabilized and activated through posttranslational modifications, including methylation, phosphorylation and acetylation, 53 which regulate gene transcription and affect a series of signaling pathways involved in apoptosis, cell cycle arrest, senescence, autophagy, ferroptosis, cellular metabolism and the tumor immune microenvironment (TME) 54,55,56 (Fig

8ac), M1 macrophage increase (Supplementary Fig

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