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a,b,c Mechanistically, the At LDOX catalysed hydroxylation of 3,4- cis -leucocyanidin ( 6 ) may result in hydroxylation products at C 2 ( a ), C 3 ( b ) or C 4 ( c )

Kosower NS, Kosower EM, Wertheim B, Correa WS

Given that some mutant enzymes retain low-level FAD-binding capacity, a gene + high-dose riboflavin synergy strategy has been proposed: in AIFM1 encephalopathies, low-level AAV transduction re-establishes baseline protein expression, while daily riboflavin doses above 400 mg act as a molecular chaperone to stabilize FAD binding a regimen shown to improve ICARS scores and neuroimaging outcomes (54, 75)

Although pharmacological efficacy of some drugs was claimed to be improved after administration of developed derivatives compared to parent drug dosing, in these studies, the derivatives as such were either shown to be active or their activity has not been investigated