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First, a seemingly dramatic change in the unbound fraction from 1% to 10% releases less than 5% of the total amount of drug in the body into the unbound pool because less than one third of the drug in the body is bound to plasma proteins even in the most extreme cases, eg, warfarin

J Pharmacol Exp Ther 255:13771384 Beiu AM, Noveanu L, Hncu IM, Lascu A, Petrescu L, Maack C, Elmr E, Muntean DM (2022) Mitochondrial effects of common cardiovascular medications: the good, the bad and the mixed

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