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5B) was most likely due to its flux into NADP(H) production, where NADPH is required by xenobiotic detoxification enzymes for the metabolism of Dox

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demonstrated on-resin peptide macrocyclization via thiol-ene reaction between Cys and terminal alkene bearing side chains of four to six carbons in length (Zhao et al., Figure 2C), sequence compatibility was investigated through variations of the pentapeptide model to include Arg, Glu, Gly, Lys, Pro, Trp, and Tyr in varying combinations with four and five carbon alkene side chain bearing unnatural amino acids