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How GLP-1 Medications Differ from Other Weight Loss Drugs: Traditional Weight Loss Medications: Stimulants (phentermine): Increase energy, suppress appetite through adrenaline-like effects Fat blockers (orlistat): Prevent fat absorption in intestines Combination pills (Contrave, Qsymia): Multiple mechanisms, moderate effectiveness These produce 3-9% average weight loss at best

Reconstitution Reconstitute only under an approved laboratory protocol using the diluent and final concentration specified for the study

P-rank scores show that SGLT-2 inhibitors were ranked first in reducing CV death (84.8%) (Additional file 1: Table S2)