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First, chronic hyperglycemia leads to a decrease of insulin biosynthesis and/or secretion in the diabetic state, which is accompanied by decreased expression of insulin transcription factors

Many clients pair vitamin C with zinc for enhanced immune support, B vitamins for energy, glutathione for antioxidant protection, or NAD+ for cellular optimization

Extensive scientific evidences have also shown that in the gut, metformin can also increase the secretion of glucagon-like peptide-1 (GLP-1) by L cells (Kim et al., 2014