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10,11 A rapid decay in circulation, coupled with less than 2 minutes of half-life of GLP-1 by dipeptidyl peptidase-IV (DPP-IV), caused researchers to develop GLP-1R agonists or DPP-IV inhibitors aimed at maintaining the effects of GLP-1 in pharmacological or physiological concentration, respectively

Eur Polymer J

Since the discovery and functional verification of GLP-1 in the 1980s ( However, the therapeutic utility of native GLP-1 was limited by its rapid enzymatic degradation and short plasma half-life, which prompted the development of longer-acting receptor agonists