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Sickle hemoglobin-containing red blood cells are tougher than regular red blood cells in circulation, in contrast to these alterations

The evolutionary advantage this provides is not fully understood but may in part relate to its neuroprotective properties discussed below, although it comes at a substantial cost associated with the incidence of, for example, gout and cardiovascular disease 1

(PubMed) de Koning EJ, van der Zwaluw NL, van Wijngaarden JP, et al

N-acetylcysteine amide has been reported to inhibit H2O2-induced cataract formation ex vivo at concentrations of 0.1 to 10 mM (144), as well as selenite and l-buthionine-(S, R)-sulfoximine-induced cataracts in vivo at an intraperitoneal injection dose of 250 mg/kg/day (145,146)