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[54] demonstrated that allicin promotes vasorelaxation through both the NO-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) pathway and prostacyclin-adenylyl cyclase-cyclic adenosine monophosphate (PGI2-AC-cAMP) pathway via H 2 S production, thus exhibiting robust anti-hypertensive effects in SHRs

F.et al (2013)