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doi: 10.1155/2020/6805354

Elevated levels of circulating biomarkers related to leaky gut syndrome and bacterial translocation are associated with Graves disease

An intriguing finding is that f-type TRX is glutathionylated on a cysteine residue external to the active site, decreasing its activity against target proteins such as plastidial NADP-glyceraldehyde3-phosphate dehydrogenase (GAPDH

Structurally, it consists of D-ribose, a pentose sugar involved in cellular energy metabolism, chemically bound to L-cysteine, an amino acid required for glutathione biosynthesis