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Clinical trials have shown body weight reductions of 15 to 20% in some participants, which explains why these medications have exploded in popularity beyond diabetes treatment (Wilding et al., 2021, New England Journal of Medicine)

The medication has a half-life of approximately five days, meaning therapeutic effects persist for several weeks after the final dose but eventually resolve completely

Children with ASD commonly exhibit increased intestinal permeabilityoften referred to as leaky gutwhich allows microbial metabolites, such as short-chain fatty acids (SCFAs) and neuroactive compounds (e.g., 5-HT, GABA), to enter systemic circulation (Ullah et al., 2024)