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**Do not use if you see:** - Any cloudiness or haziness, even faint - A yellowish or brownish tint - Particles, fibers, or specks floating in the solution - Gel-like clumps or strands If your pen has been frozen (even if it has thawed and looks normal), do not use it

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Statistical analysis Statistical analyses were performed using GraphPad Prism version 7.0 (San Diego, CA, USA)

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