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Contamination is the enemy of good science

192,193 For example, one research group used LNPs to deliver mRNA encoding erythropoietin into mouse fetuses, thus increasing erythropoietin protein levels in the mouse bloodstream

The sustained tonic GH/IGF-1 elevation it produces rather than pulsatile bursts is both a research advantage (easier to measure steady-state changes in body composition) and a design consideration (it does not replicate physiological GH pulsatility, which may matter in neuroendocrine studies)

Overall, these results show that a 3-month clinical intervention with L-GSH supplementation in T2DM subjects resulted in significantly decreased levels of the proinflammatory cytokine IL-6, and a decrease in the oxidative stress marker MDA