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In the extracellular part of the receptor, GIPs His18 forms hydrogen bonds with the receptors Tyr36, which in turn forms pi-stacking interactions with GIPs Phe22 (Figure 4, inset3)

Summary Keywords endocrinology, growth hormone secretagogues, IGF-1 analogues, off-label use, peptide hormones, performance-enhancing drugs, sports doping Citation Dominikowski A, Rko Z, Olejarz M, Szczepanek-Parulska E, Domin R and Ruchaa M (2026) The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration

Association between cancer incidence rate and mortality Large scale epidemiological studies have shown that serum IGF-1 levels are positively correlated with the risk of breast cancer, prostate cancer and colorectal cancer