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Lin and co-workers rationally designed a single-atom Pd nanozyme (Pd SAzyme) with atom-economical utilization of catalytic centers (Figure 1A)

Lysis was achieved by incubating on a rotating wheel at 25 r.p.m

Age (Dordr.) 2013;35:15311544

A novel miR-338-3p/SLC1A5 axis has been identified as a key regulator of oxidative stress-induced ferroptosis in DR: high glucose significantly upregulates miR-338-3p expression in RPE cells, and miR-338-3p silencing reverses RPE cell death and ferroptosis ( Although studies have confirmed that the three components form a positive-feedback loop that drives DR progression and that antioxidant therapy can alleviate DR pathology, the key molecular triggers that initiate the loopsuch as the cell-specific mechanisms by which hyperglycemia induces excessive ROS production in different retinal cellsremain poorly defined