can semaglutide cause mood swings Psychiatric adverse events associated with semaglutide, liraglutide and tirzepatide: a pharmacovigilance analysis of individual case safety reports submitted to the EudraVigilance database GLP-1 Mood Changes: Side Effects

COX-2 catalyzes the synthesis of prostaglandin E 2 (PGE 2 ) (Ilari et al., 2020), while iNOS produces nitric oxide (NO), which together contribute to the formation of reactive nitrogen species (RNS) (Zhao et al., 2022), thereby exacerbating tissue inflammation and oxidative injury

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Outcomes (e.g., mortality, rebleeding/recurrence, seizures, hydrocephalus) were assessed at 6 and 12 months

The limitations of this work are that we included RCTs, non-RCTs, and observational studies, which may lower the overall quality of evidence of the included studies