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The functional abnormalities of tumor-associated endothelial cells and the microvascular heterogeneity could explain, at least in part, the reduced efficacy of anti-angiogenic therapy in breast cancer by enabling endothelial cells an increased pro-angiogenic activity to acquire drug resistance (Grange et al., 2006

(a) Open field anxiety test quantified as number of gridlines crossed, with results shown for normal C57BL/6J mice pre- and post-vehicle control or MT-II treatment for 9 days (vehicle, n = 7

It reduces renal clearance and enzymatic degradation, enabling once-weekly administration

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