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Impaired gut barrier function, also referred to as a leaky gut, which may disrupt the balance between tolerance and immunity to non-self-antigens, is often observed in autoimmune diseases

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One of the widely used behavioral paradigms for rodents to check visuospatial memory is the Morris water maze (MWM), where the animals need to find an escape platform in a pool filled with water, allowing different arrangements with distal or proximal visual cues and with a hidden (spatial learning task) or visible (visual guidance task) platform