COBAS analysis Plasma samples were analyzed for alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglycerides, cholesterol, LDL, HDL, and albumin using a Cobas c111 (Roche Diagnostics) automated clinical chemistry analyzer that was calibrated according to manufacturer guidelines
Without insurance, costs remain high, but the program still includes medical oversight and coaching support
In addition, a meta-analysis of 1193 patients with baseline SGLT2i use in AMPLITUDE-O and Harmony Outcomes revealed an HR for MACE of 0.78 (95% CI 0.491.24) with SGLT2is and 0.77 (95% CI 0.680.87) without SGLT2is ( P -value for interaction 0.95), and an HR for HHF of 0.34 (95% CI 0.120.96) with SGLT2is and 0.72 (95% CI 0.550.92) without SGLT2is ( P -value for interaction 0.18) [48]
Trial data consistently show that patients who rush escalation have more nausea and vomiting, while those who stay on each step for the full month tolerate the drug better
