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Static carbamidomethylation (+ 57.021 Da) was applied to cysteine residues, while dynamic oxidation (+ 15.995 Da) was applied to methionine residues

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HCV infection also induces oxidative stress by impairing the thiol/disulfide balance, while direct-acting antiviral therapy restores this balance and decreases the pro-fibrotic process in patients with chronic hepatitis C 101