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Obesity treatment is costly and time-consuming and puts pressure on both the patient and the healthcare system

In addition, ROS mediates the oxidation of Cysteine thiols of a family of Ca 2+ transporters

Consultation with reproductive endocrinology specialists may benefit individuals with complex fertility issues or significant obesity-related comorbidities

There are two hit theories, the first hit for mitochondrial GSH depletion and ROS production and the second hit for JNK activation and translocation into mitochondria, aggravating ROS generation and mitochondrial membrane permeability transition (MPT), leading to hepatocyte death [5]