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2,3 Mechanistic explanations for the development of CI secondary to constipation include reduced efferent vagal cholinergic activity resulting in reduced colonic blood flow, as well as increased intracolonic luminal pressure resulting in reduced colonic blood flow with mucosal-to-serosal shunting of blood

Chemla, J

Studies were excluded if they enrolled paediatric populations, involved animal or in vitro experiments, reported only metabolic or cardiovascular outcomes without respiratory adverse-event data, or were narrative reviews, editorials, or commentaries without primary data

Just avoid taking them with high-sugar foods or heavy caffeine, as these can increase oxidative stress and force the antioxidants to work on the "cleanup" of your meal rather than the repair of your tissues