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Unlike the monoamine system with the main role of providing extrinsic inputs to the cerebral cortex, Glutamate provides both excitatory and inhibitory control of information flow in the brain (132, 137, 138)

For this reason, treatments such as peptide therapy must always be administered under the supervision of a clinician

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Moreover, few studies have investigated off-target activation in normal tissues where GSH levels may still be substantial (e.g., liver, kidney)