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DPP-4 inhibitors have the advantage of decreasing glucagon by augmenting levels of incretin hormones, particularly driving insulin secretion in hyperglycemia to avoid glucagon overproduction

The insulin-enhancing effects of GIP and GLP-1 were discovered over 25 years ago, yet new roles for incretin hormones continue to emerge [30]

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Yet, most of the A PET (such as AV-45) or Tau detection fails to produce a full neurodegenerative map due to the limited penetration of the tracers across the BBB