Therefore, the ability of GLP-1 receptor agonists to reach central targets via the nasal route should be interpreted cautiously and in direct relation to their physicochemical properties, including size, enzymatic stability, and affinity for transporter systems
Interplay between GLP-1 Signaling and Muscle Metabolism GLP-1RAs modulate metabolism through multiple intracellular signaling pathways, including cAMP/PKA, PI3K/Akt, and SIRT1-mediated cascades, influencing glucose uptake, mitochondrial function, and inflammatory responses [82], which may contribute to interactions between GLP-1RA therapy and skeletal muscle metabolism, potentially affecting muscle metabolism and quality
The Effect of Berberine Supplementation on Obesity Parameters, Inflammation and Liver Function Enzymes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Its part of a group of GLP-1 type 2 diabetes drugs