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Strikingly, through exploring multiple immunotherapy datasets, we further discovered that high IL16 expression was associated with favorable survival in cancer patients who received PD-1/PD-L1 therapy, including two non-small cell lung cancer cohorts 36,37 , one hepatocellular carcinoma cohort 38 , one head and neck cancer/melanoma/lung cancer mixed cohort 39 , and one melanoma cohort 40