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Overview of SNAC as a Drug-Delivery Technology Various compounds, including surfactants, bile salts, bacterial toxins, chelating agents, and medium-chain fatty acids, have proven effective as absorption enhancers in vitro and in vivo (7)

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Other groups have reported increased efficacy with 5FU and metformin in models of acquired resistance 53,54,55,56 , in spheroid culture 53 or xenograft/PDX models 57,58,59 , but the potential of combined 5FUCI inhibitor co-treatment in a chemo-naive, immune-competent setting requires further investigation