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A vast number of preclinical and clinical studies have provided evidence for the potential role of GLP-1R agonists in modulating reward-seeking of food, alcohol, cocaine, and amphetamine, offering the possibility of a novel therapeutic alternative for treating addiction [112]

Over 5,000 scientific studies have been performed with berberine, including over 150 human clinical trials

[1] [3] Decisions about whether to continue or temporarily pause these medications are individualised based on factors such as: The specific GLP-1 medication and dosage Whether you're in a dose-escalation phase Presence of gastrointestinal symptoms Type and urgency of surgery Individual risk factors for aspiration Standard UK fasting guidance typically recommends 6 hours for solids and 2 hours for clear fluids before surgery

& Cowtan, K