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Oral Formulations oral GLP-1 are 1) much easier to manufacture at scale compared to the current injectable GLP-1 drugs, 2) much simpler to distribute globally, given no need for cold-chain storage, 3) more attractive for needle-phobic patients who avoid the injectable GLP-1 drugs currently available, and 4) better suited to long-term maintenance therapy, given what we expect will be lower pricing (and lower costs) for orals compared to injectable GLP-1 drugs

The relevance for autoimmune patients includes potential effects on bone density (important for patients on corticosteroids or with conditions like lupus that increase osteoporosis risk) and additional anti-inflammatory pathways that GLP-1-only drugs do not activate

After 3 h, the medium was removed and replaced with medium as follows: HUVEC and HDMEC were cultured in endothelial cell basal medium supplemented with 2% (HUVEC) or 1% (HDMEC) FCS, and 90 g ml 1 heparin, with or without hHGF or dimeric macrocycle