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During sleep, the body: Repairs tissues and muscles Consolidates memory Regulates hormones (including growth hormone and cortisol) Strengthens immune function Sleep is regulated by the circadian rhythm , the bodys internal clock, which is influenced by external cues like light and temperature

Previously, we have described the mechanism underlying the development tubular injury of DKD, here we reviewed the protective effect of hypoglycaemic drugs on renal tubules ( Table 1 ), and some new therapeutic strategies, such as stem cell therapies

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Furthermore, the review delves into the potential pathophysiological mechanisms underpinning these associations, with emphasis on bacterial translocation, systemic inflammation, immune dysregulation, and oxidative stress pathways