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In fact, a meta-analysis of clinical trials found a modest benefit for individuals with mild cognitive impairment, though a separate systematic review concluded more evidence is needed before clinical recommendations can be made

The total number of actin enriched spines adjacent to VGLUT1 or Synapsin were counted and converted to a percentage as the percent correlation of treatment-induced spines to presynaptic markers is a strong indicator of ability to transmit excitatory signals

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