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Acute injuries often respond well to 250-300mcg, while chronic or severe injuries may benefit from 400-500mcg

Microglia-derived TNF- and IFN- exacerbate ERS by inhibiting neuronal XBP1 splicing, while astrocyte-secreted complement protein C1q enhances synaptic pruning, intensifying ER folding stress [217,218]

McCoy et al., Journal of Pharmacology and Experimental Therapeutics (2013) Foundational research examining the biochemical and cellular mechanisms of Dihexa in cell signalling and neurobiological contexts

pSS was diagnosed according to the 2016 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria ( Histological staining The LSG samples were fixed in fresh 4% neutral formaldehyde overnight, placed into an automatic tissue dehydrator for dehydration, embedded in paraffin, and cut into 5-mm-thick serial sections for haematoxylin and eosin (HE) and immunohistochemical (IHC) staining