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Vitamin B12 overdose primarily occurs not through a normal diet, but through the intake of high-dose supplements or medications

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In neurological models, kainic acid was administered to rats via a cannula in the lateral cerebral ventricle to induce neurotoxicity

14 Natives or long-term high-altitude sojourners, who are chronically exposed to altitude hypoxia, may develop several altitude-related illnesses, including polycythemia, systemic hypertension, pulmonary hypertension, congenital heart disease, thromboembolic disease, lung disease, mental deterioration, as well as pregnancy and neonatal problems