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However, its successful application will require further elucidation of TREM biology in humans, regarding the cell-type specificity of TREM expression (e.g., in astrocytes, oligodendrocytes, and neurons), species differences between humans and mice, immature metabolic and mitochondrial features of in vitro culture (e.g., BV and iPSC-derived cells), early-onset or late-onset, and the temporal dynamics of disease progression with senescence

to arsenate and arsenite exposure

These short-term benefits are most pronounced for individuals who were previously deficient or had low baseline levels of Vitamin B12

Avakh A, Grant GD, Cheesman MJ, Kalkundri T, Hall S