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Recently, Wang Yongxiang and colleagues provided the first evidence that activation of microglial glucagon-like peptide-1 receptor (GLP-1R) in the spinal cord specifically suppresses neuropathic pain, cancer pain, and diabetic hypersensitivity [20]

Barcoded peptide and polymer libraries allow parallel evaluation of thousands of candidates, rapidly identifying synergistic sequences that can be modularly integrated into GLP-1R-targeted nanoscaffolds for cargo- and disease-specific optimization [544, 545]