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Long used in Indian and Chinese traditional medicine, berberine is described by Apollo Hospitals as a naturally occurring alkaloid associated with anti-microbial, anti-inflammatory and metabolic regulatory properties

It has been shown that modification of the C-3 position can effectively enhance the antiproliferative ability of caudatin against various cancer cell lines compared to the parent compound, presumably due to improved membrane permeability facilitated by increased lipophilicity (Figure 1g) exhibited the highest activity against HepG2 cells (IC 50 3.11 M) ( To summarize, the esterification and glycosylation of C-3 OH might be beneficial for improving bioactivity and lipid solubility

Pharmacologic inhibition of FSP1 provided notable therapeutic benefit in preclinical lung cancer models, and FSP1 expression had prognostic associations in lung cancer, supporting translational relevance 80