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Volkow notes that such a mechanism could interfere with that incentive, motivational drive, that consumption reinforces and generates in our brain it just blocks it. That is of course extremely important for drugs, because thats what drugs do: Immediately activates a system, and you just want more and more and more and it escalates

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Similarly, in the STEP 2 trial, which involved over 1,200 adults with type 2 diabetes and overweight or obesity, participants who received semaglutide had significantly greater weight loss and better glycemic control compared to those who received placebo

At the same time, the analgesic effect of the B complex vitamins enhances the healing effect