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Read clinical review Clinician-reviewed guide to switching between Zepbound (tirzepatide) and Trulicity (dulaglutide), covering dose mapping, washout timing, side effects, and what the trial data says about efficacy differences

In ELIXA, the effects of lixisenatide versus placebo in 6,026 people with T2D and a recent acute coronary event were investigated

However, it should also be recognized that it may be difficult to definitively demonstrate whether DPP-4 does play a physiologically relevant role in cleaving some endogenous substrates in vivo because it can be difficult to distinguish between the intact substrate and the truncated metabolite (because assays are not specific or sensitive enough) and/or because it may be difficult to obtain appropriate samples (e.g., from synapses [neurotransmitters] or interstitial fluid [paracrine signallers])

Nutrient shortfalls Eating smaller amounts can also reduce the intake of protein, iron, vitamin B12, folate and other nutrients