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In the 1980s, when the work on gastric juices began, funding for Croatian scientists was limited, Sikiric said, and there were few opportunities to engage with Western researchers

Prior efforts to treat obesity demonstrate that sustained weight reduction is a Herculean task--thus it may be the case that GLP-1 agents will need to be administered chronically to sustain anti-obesity benefits

European Multicentre Orlistat Study Group Lancet