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Bowden J, Holmes MV

We, therefore, used alternative approaches and have determined the structure of a high molecular weight TrxR subfamily member using cryo-EM, demonstrating the feasibility of this methodology to study this protein subfamily of importance in several human diseases (PDB ID 8A1R, EMD-15084) (Fig

Cardiac-specific Trx1 expression increases the LC3-II/LC3-I ratio and PPAR- coactivator 1- levels, indicating enhanced mitochondrial autophagy to eliminate dysfunctional mitochondria and mitigate sepsis-induced myocardial dysfunction (129)

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