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The cardiovascular benefits of GLP-1-RAs arise primarily through indirect systemic mechanisms, with limited evidence supporting direct effects on cardiomyocytes ( Figure 1 )

Ralf Jockers (Inserm/CNRS, Universit Paris Cit), researchers have found the significant role of DNA mutations in the glucagon-like peptide 1 receptor (GLP1R) and their profound effects on metabolic traits related to diabetes and obesity

10.1074/jbc.M611090200 88

The general approach to management of osteoporosis and osteopenia is as follows: Nutritional and nonpharmacologic interventions All women, not just those with low bone massshould aim for an adequate intake of vitamin D and calcium, participation in weight-bearing and muscle-strengthening exercises, smoking cessation as applicable, minimization of alcohol intake as applicable, and treatment of risk factors for falling