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Acknowledgements This work was partly supported by Associazione Italiana Ricerca sul Cancro (AIRC) (IG2014-15197 to L.F.) and by grants from the University of Chieti-Pescara G

Patients with polycythemia vera a blood disorder involving overproduction of red blood cells face additional risks since B12 stimulates red blood cell production

The so-called Warburg effect (or aerobic glycolysis) has become a well-known and common metabolic phenotype allowing tumors to fulfil the energetic requirement for cell growth [3]