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By reducing caloric intake through appetite suppression, improving insulin sensitivity, and directly stimulating hepatic lipid clearance, retatrutide may address multiple drivers of metabolic dysfunction-associated steatotic liver disease (MASLD) terminology increasingly used in UK and European clinical practice, though many NHS and NICE materials continue to use the older designation of non-alcoholic fatty liver disease (NAFLD)

Additionally, GLP-1s decrease appetite

However, human evidence remains limited and inconsistent

In addition to lowering the levels of blood glucose, as shown in Figure 1 , GLP-1RAs have also been shown to have a positive effect on multiple human tissues