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Recovery and sleep quality: anecdotal reports are common, but no validated outcome measures in published trials

Notably, experiments in mice showed that a high-fat diet or clock-disrupting conditions alter microbial rhythms, which then contributes to hepatic circadian clock dysfunction and obesity

While the beneficial effects of low IGF-1 action on aging seems well supported by data in model systems 6,7 and unique human populations 13,16 , a broader examination of the literature suggests that a more nuanced, complex, and controversial relationship exists between IGF-1, aging, and disease, which is indicative of the pleiotropic actions attributed to IGF-1 in cells and tissues 12,19

Eliaschewitz, F