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Reusch, J

It generally has a strong safety profile, but be aware that it can interact with certain medications

doi: 10.3389/fphar.2026.1736380 Received 10 November 2025 Revised 20 January 2026 Accepted 21 January 2026 Published 10 February 2026 Volume 17 - 2026 Edited by Madhusudan Prasad Singh, All India Institute of Medical Sciences Raipur, India Reviewed by Hemasri Velmurugan, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), India Prachi Arunima, All India Institute of Medical Sciences Raipur, India Updates Copyright 2026 Wali, Rangraze, Khan, Mufti, El-Tanani and Rizzo

The insertion of selenocysteine (Sec) during translation involves a unique set of specialized translational cofactors, including a Sec-specific elongation factor, a tRNA Sec that recognizes the UGA codon, and RNA binding proteins, such as SBP2 (SECIS binding protein 2) that bind to stem-loop structures in the 3-untranslated region of the selenoprotein transcripts denoted selenocysteine incorporation sequence or SECIS (for review see [64, 65])